Abstract | INTRODUCTION: GOAL: The purpose of this study was to investigate percentage of positive COX-2 expression in skin tumors, including pre-malignant and malignant tumors. METHODS: This is an analytic cross-sectional study that includes 62 skin tumor samples, among which 49 samples were malignant and 13 were pre-malignant. After study for determination of pathologic kind of tumors, samples underwent immunohistochemical study for COX-2 expression. The DakoCytomation EnVision+System-HRP is a two-step extremely sensitive IHC staining technique which we used in this study. RESULTS: CONCLUSION: COX-2 expression was positive in skin tumors including malignant and pre-malignant skin lesions. This study strongly suggests that COX-2 can be one of the molecular targets in treating various skin tumors.
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Authors | Mehdi Amirnia, Arash Babaie-Ghazani, Ashraf Fakhrjou, Effat Khodaeiani, Hossein Alikhah, Mohammad Naghavi-behzad, Armin Zarrintan |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 25
Issue 5
Pg. 380-7
(Oct 2014)
ISSN: 1471-1753 [Electronic] England |
PMID | 22667343
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bowen's Disease
(metabolism)
- Carcinoma, Basal Cell
(metabolism)
- Carcinoma, Squamous Cell
(metabolism)
- Cross-Sectional Studies
- Cyclooxygenase 2
(biosynthesis)
- Female
- Humans
- Immunohistochemistry
- Keratosis, Actinic
(metabolism)
- Male
- Middle Aged
- Skin
(metabolism)
- Skin Neoplasms
(metabolism)
- Young Adult
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