[Sustained efficacy of alpha-interferon therapy combined with Yixuesheng Capsule in treatment of chronic hepatitis B].

Abstract

OBJECTIVE:

To observe the difference between the combination therapy of alpha-interferon (IFN-alpha) therapy Yixuesheng Capsule and the monotherapy of IFN-alpha in treatment of chronic hepatitis B.

METHOD:

A total of 288 patients with HBeAg-positive chronic hepatitis B proven by liver biopsy were included in this study. During the individualized therapy, they received hypodermic injection of IFN-alpha 1b, with 5 MU x time(-1) and three times x w(-1). Of them, 125 patients received combination therapy with Yixuesheng Capsule for three months, with 1.0 g/time and three times/d; and 163 patients received only IFN-alpha 1b (the IFN-alpha monotherapy group). After the course of therapy, all patients were followed up for at least 24 months. The intention-to-treat analysis was adopted for statistic analysis.

RESULT:

The two groups showed no statistical significance by gender, age, liver necroinflammation grading, liver fibrosis staging, serum ALT levels, serum HBV DNA levels and IFN-alpha therapy course. The whole course and the 24-month follow-up visit cover all of 112 patients in the combination treatment group and 141 cases in the IFN-alpha monotherapy group. The response rates of the combination treatment group and the IFN-alpha monotherapy group were 48.0% (60/125) and 35.0% (57/163) (x = 4.980, P = 0.026) at the end of treatment, respectively, 45.6% (57/125) and 33.1% (54/163) (x2 = 4.645, P =0.031) at the end of 12-month-follow-up period, respectively, and 38.4% (48/125) and 32.5% (53/163) (x2 = 1.076, P = 0.300) at the end of 24-month follow-up period, respectively.

CONCLUSION:

The combination treatment with IFN-alpha and Yixuesheng Capsule shows a slightly better sustained efficacy on HBeAg-positive chronic hepatitis B patients compared with IFN-alpha monotherapy.

• Authors: Qianguo Mao, Yayong Su, Chuncheng Wu, Zhicheng Duan, Jinmo Tang, Chongi Gu, Huiqing Liang, Jiaen Yang, Lijian Huang, Ying Zheng, Min Wang, Xianqiong Gong
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 37 Issue 4 Pg. 537-40 (Feb 2012) ISSN: 1001-5302 [Print] China
• PMID: 22667159 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Interferon-alpha
• yixuesheng

Topics

• Adult
• Capsules
• Combined Modality Therapy
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Follow-Up Studies
• Hepatitis B, Chronic (drug therapy)
• Humans
• Interferon-alpha (therapeutic use)
• Male
• Treatment Outcome