Abstract | BACKGROUND: MATERIALS AND METHODS: The experiments were conducted on 4-week male SD rats (120-150g). The salivation was induced by intraperitoneally administrated pilocarpine and saliva was collected using preweighted small cotton balls inserted into the animal's mouth every 30 min for 180 min. Thirteen minutes before intraperitoneal administration of pilocarpine, rebamipide, mosapride, and risperidone were administered intraduodenally. Control rats were conducted by intraperitoneal administration of saline and intraduodenal administration of 0.5% methylcellulose solution. RESULTS: The saliva weight at 0-30 min was significantly (p<0.01) increased after administration of pilocarpine, compared to control rats. An additional administration of mosapride and rebamipide increased the saliva weight at 0-30 min. The total volume of saliva for 150 min after administration of pilocarpine was the highest after preadministration of rebamipide, followed by mosapride, and risperidone. CONCLUSIONS:
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Authors | Yoshihisa Urita, Toshiyasu Watanabe, Tadashi Maeda, Yosuke Sasaki, Kazuo Hike, Hiroshi Muto, Masaki Sanaka, Nagato Shimada, Hitoshi Nakajima, Motonobu Sugimoto |
Journal | North American journal of medical sciences
(N Am J Med Sci)
Vol. 1
Issue 3
Pg. 121-4
(Aug 2009)
ISSN: 2250-1541 [Print] India |
PMID | 22666683
(Publication Type: Journal Article)
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