ZHENG is the key theory in
traditional Chinese medicine (TCM) and it is very important to find the molecular pharmacology of traditional Chinese herbal formulae. One ZHENG is related to many diseases and the herbal formulae are aiming to ZHENG. Therefore, many herbal formulae whose effects on a certain disease have been confirmed might also treat other diseases with the same ZHENG. In this study, the microarrays collected from patients with QiXuXueYu ZHENG (Qi-deficiency and Blood-stasis syndrome) before treatment and after being treated with
Fuzheng Huayu Capsule were analyzed by a high-throughput gene microarrays-based
drug similarity comparison method, which could find the small molecules which had similar effects with
Fuzheng Huayu Capsule. Besides getting the results of anti-inflammatory and anti-
fibrosis drugs which embody the known effect of
Fuzheng Huayu Capsule, many other small molecules were screened out and could reflect other types of effects of this formula in treating QiXuXueYu ZHENG, including anti-hyperglycemic, anti-hyperlipidemic, hyposenstive effect. Then we integrated this information to display the effect of
Fuzheng Huayu Capsule and its potential multiple-target molecular pharmacology. Moreover, through using clinical blood-tested data to verify our prediction,
Fuzheng Huayu Capsule was proved to have effects on diabetes and
dyslipidemia.