Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: The patients in the control group experienced significantly ≥ grade 2 and ≥ grade 3 neurotoxicity (by NCI CTCAE grading) than those in the neurotropin group (60.9 vs. 21.1 %, for at least grade 2 neurotoxicity, P = 0.001; 39 vs. 2.7 %, for at least grade 3 neurotoxicity, P < 0.001). If neurotoxicity was assessed by oxaliplatin-specific neurotoxicity grading, the patients in the control group also experienced significantly more ≥ grade 2 neurotoxicity (51.2 vs. 12.5 %, P = 0.001). Neurotropin was the only factor that affected the incidence of ≥ grade 2 neurotoxicity in the multivariate Cox proportional hazards regression analysis. CONCLUSION:
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Authors | R X Zhang, Z H Lu, D S Wan, X J Wu, P R Ding, L H Kong, Z Z Pan, G Chen |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 27
Issue 12
Pg. 1645-50
(Dec 2012)
ISSN: 1432-1262 [Electronic] Germany |
PMID | 22664945
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuroprotective Agents
- Organoplatinum Compounds
- Polysaccharides
- Oxaliplatin
- neurotropin
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Topics |
- Colorectal Neoplasms
(drug therapy, pathology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Staging
- Neuroprotective Agents
(therapeutic use)
- Neurotoxicity Syndromes
(etiology, pathology)
- Organoplatinum Compounds
(adverse effects)
- Oxaliplatin
- Pilot Projects
- Polysaccharides
(therapeutic use)
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
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