Abstract | BACKGROUND: METHODS AND RESULTS: In 216 consecutive patients with ST-segment elevation myocardial infarction ( STEMI) after successful primary PCI, data were collected and analyzed on epicardial coronary flow, ST-segment resolution (STR) on electrocardiography, maximum serum creatine kinase levels, and the incidence of major adverse cardiac events ( MACE). The prevalence of MetS was 40.7% (88 patients). Corrected Thrombolysis In Myocardial Infarction frame count was significantly higher in the MetS group than in the non-MetS group (28.1±9.4 vs. 24.7±7.9, P=0.04). STR ≥50% was observed in 51.1% and 69.5%, respectively (P=0.01). Patients with MetS also had higher maximum creatine kinase levels (3,470±2,320IU/L vs. 2,664±1,850IU/L, P=0.01). On logistic regression analysis after adjustment for confounders, MetS was an independent negative predictor of complete STR (odds ratio, 0.49; 95% confidence interval [CI]: 0.25-0.95, P=0.03). On Cox multivariate analysis, MetS was an independent predictor for MACE (hazard ratio, 4.85; 95% CI: 1.28-18.3, P=0.02). CONCLUSIONS: MetS may damage microcirculation after direct PCI in patients with STEMI and lead to poor prognosis.
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Authors | Yasuhiro Uchida, Satoshi Ichimiya, Hideki Ishii, Masaaki Kanashiro, Junji Watanabe, Daiji Yoshikawa, Kyosuke Takeshita, Shinichi Sakai, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 76
Issue 8
Pg. 1972-9
( 2012)
ISSN: 1347-4820 [Electronic] Japan |
PMID | 22664935
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Aged
- Coronary Circulation
- Creatine Kinase
(blood)
- Humans
- Incidence
- Male
- Metabolic Syndrome
(blood, etiology, physiopathology)
- Microcirculation
- Middle Aged
- Myocardial Infarction
(blood, complications, physiopathology, therapy)
- Percutaneous Coronary Intervention
- Prevalence
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