Psychotic aura symptoms in familial hemiplegic migraine type 2 (ATP1A2).

Abstract

INTRODUCTION:

Neuropsychological symptoms are rare in familial hemiplegic migraine (FHM). There are no reports of psychotic symptoms in FHM type 2 (ATP1A2). We examined a family with a FHM phenotype due to a M731T mutation in ATP1A2. A 10-year follow-up allowed us to observe complex auras, including psychotic symptoms in two siblings.

CASE REPORT:

Male, 48 years old, with an aura that included complex illusions with a feeling of time travelling, coincident with other aura features. The aura was regarded as mystical by the patient. Female, 38 years old, with a complex migraine aura, during which she believed she had the ability to time travel and was being followed by lobbyists who wanted to steal this ability from her.

DISCUSSION:

FHM type 2 must be included in the list of differential diagnoses of acute psychosis in patients with a previous history of migraine aura.

• Authors: José Barros, Alexandre Mendes, Ilda Matos, José Pereira-Monteiro
• Journal: The journal of headache and pain (J Headache Pain) Vol. 13 Issue 7 Pg. 581-5 (Oct 2012) ISSN: 1129-2377 [Electronic] England
• PMID: 22661290 (Publication Type: Case Reports, Journal Article)

Chemical References

• ATP1A2 protein, human
• Sodium-Potassium-Exchanging ATPase

Topics

• Adolescent
• Adult
• Child
• Epilepsy
• Female
• Humans
• Male
• Middle Aged
• Migraine with Aura (complications, genetics)
• Mutation
• Pedigree
• Psychotic Disorders (diagnosis, etiology, genetics)
• Sodium-Potassium-Exchanging ATPase (genetics)
• Young Adult