Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic).

Abstract

In a study of the pain-relieving effect of 3 drugs commonly used to treat acute renal colic in this hospital, intravenous indomethacin and intramuscular diclofenac (prostaglandin synthetase inhibitors) were compared with intravenous Avafortan (analgesic antispasmodic). As first-line analgesics, prostaglandin synthetase inhibitors, if given intravenously, offer an effective alternative to Avafortan. Of 145 patients studied, 32 required a second injection for complete relief of pain. Administering a second dose of prostaglandin synthetase inhibitors resulted in equally significant pain relief rate even though the route was intramuscular.

• Authors: A E el-Sherif, R Foda, L J Norlen, H Yahia
• Journal: British journal of urology (Br J Urol) Vol. 66 Issue 6 Pg. 602-5 (Dec 1990) ISSN: 0007-1331 [Print] England
• PMID: 2265331 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Anti-Inflammatory Agents, Non-Steroidal
• Drug Combinations
• Phenylacetates
• camylofin, dipyrone drug combination
• Diclofenac
• Dipyrone
• Glycine
• Indomethacin

Topics

• Adolescent
• Adult
• Analgesics (administration & dosage, therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Colic (drug therapy)
• Diclofenac (administration & dosage, therapeutic use)
• Dipyrone (administration & dosage, therapeutic use)
• Drug Combinations
• Female
• Glycine (administration & dosage, analogs & derivatives, therapeutic use)
• Humans
• Indomethacin (administration & dosage, therapeutic use)
• Injections, Intramuscular
• Injections, Intravenous
• Kidney Diseases (drug therapy)
• Male
• Middle Aged
• Phenylacetates
• Prospective Studies