Abstract | BACKGROUND: It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy. OBJECTIVE: METHODS: Ten patients allergic to DY3 and/or DO1 were tested with a dilution series of commercial and purified DY3 and DO1 (with water-soluble parts prepared from the commercial dyes) and with naphthalene sulfonate. Nine patients were additionally tested with thin-layer chromatograms (TLCs) made from the commercial DO1 and DY3 and with paper chromatograms made from the water-soluble part of these dyes. RESULTS: Eight of nine and three of six patients tested positively to the TLCs of DO1 and DY3, respectively. Among them, 4 of 8 and 2 of 3 patients, respectively, were positive also to another spot on the TLCs. One patient was positive to the paper chromatogram from the water-soluble part of DO1. None of the tested patients reacted to naphthalene sulfonate. CONCLUSION: The results of our study suggest that there are more relevant allergens in the fat-soluble and water-soluble fractions of the commercial disperse dyes.
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Authors | Laura Malinauskiene, Erik Zimerson, Magnus Bruze, Kristina Ryberg, Marlene Isaksson |
Journal | Dermatitis : contact, atopic, occupational, drug
(Dermatitis)
2011 Nov-Dec
Vol. 22
Issue 6
Pg. 335-43
ISSN: 2162-5220 [Electronic] United States |
PMID | 22653007
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Azo Compounds
- Coloring Agents
- Dispersion Yellow 3
- Disperse Orange 1
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Topics |
- Adult
- Aged
- Allergens
(adverse effects)
- Azo Compounds
(adverse effects)
- Chromatography, Thin Layer
- Coloring Agents
(adverse effects)
- Dermatitis, Allergic Contact
(etiology)
- Female
- Humans
- Male
- Middle Aged
- Patch Tests
- Textiles
(adverse effects)
- Young Adult
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