Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells.

Abstract

We found that rejuvenation of the recipient immunity by inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss and degeneration of the spiral ganglion in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.

• Authors: Hiroshi Iwai, Muneo Inaba
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 250 Issue 1-2 Pg. 1-8 (Sep 15 2012) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 22652460 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Receptors, Interleukin-1 Type II

Topics

• Aging
• Animals
• CD4-Positive T-Lymphocytes (immunology, metabolism, transplantation)
• Disease Models, Animal
• Fetal Tissue Transplantation
• Flow Cytometry
• In Situ Hybridization
• Mice
• Nerve Degeneration (genetics, immunology, metabolism)
• Oligonucleotide Array Sequence Analysis
• Presbycusis (genetics, immunology, prevention & control)
• Receptors, Interleukin-1 Type II (biosynthesis, genetics, immunology)
• Spiral Ganglion (pathology)
• Thymus Gland (transplantation)
• Transplantation, Homologous
• Up-Regulation