Abstract | BACKGROUND: METHODS: Patients underwent either L-PCLND (n = 43) or O-PCLND (n = 24). Categorical and continuous variables were compared using the Fisher exact test and Mann-Whitney U test respectively. Overall survival was evaluated with the log-rank test. RESULTS: Primary histology was embryonal cell carcinomas (18 patients), pure seminoma (2 cases) and mixed NSGCTs (47 patients). According to the IGCCCG patients were categorized into "good", "intermediate" and "poor prognosis" disease in 55.2%, 14.9% and 20.8%, respectively. Median operative time for L-PCLND was 212 min and 232 min for O-PCLND (p = 0.256). Median postoperative duration of drainage and hospital stay was shorter after L-PCLND (0.0 vs. 3.5 days; p < 0.001 and 6.0 vs. 11.5 days; p = 0.002). Intraoperative complications occurred in 21.7% (L-PCLND) and 38.0% (O-PCLND) of cases with 19.5% and 28.5% of Clavien Grade III complications for L-PCLND and O-PCLND, respectively (p = 0.224). Significant blood loss (>500 ml) was almost equally distributed (8.6% vs. 14.2%: p = 0.076). No significant differences were observed for injuries of major vessels and postoperative complications (p = 0.758; p = 0.370). Tumor recurrence occurred in 8.6% following L-PCLND and in 14.2% following O-PCLND with a mean disease-free survival of 76.6 and 89.2 months, respectively. Overall survival was 83.3 and 95.0 months for L-PCNLD and O-PCLND, respectively (p = 0.447). CONCLUSIONS: L-PCLND represents a safe surgical option for well selected patients at an experienced center.
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Authors | Jonas Busch, Ahmed Magheli, Barbara Erber, Frank Friedersdorff, Ivan Hoffmann, Carsten Kempkensteffen, Steffen Weikert, Kurt Miller, Mark Schrader, Stefan Hinz |
Journal | BMC urology
(BMC Urol)
Vol. 12
Pg. 15
(May 31 2012)
ISSN: 1471-2490 [Electronic] England |
PMID | 22651395
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Embryonal
(drug therapy, surgery)
- Combined Modality Therapy
- Humans
- Laparoscopy
(methods)
- Length of Stay
- Lymph Node Excision
(methods)
- Lymphatic Metastasis
- Male
- Neoplasm Staging
- Neoplasms, Germ Cell and Embryonal
(drug therapy, surgery)
- Operative Time
- Prognosis
- Retroperitoneal Space
- Seminoma
(drug therapy, surgery)
- Testicular Neoplasms
(drug therapy, surgery)
- Treatment Outcome
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