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Poly(ethylene carbonate) nanoparticles as carrier system for chemotherapy showing prolonged in vivo circulation and anti-tumor efficacy.

Abstract
The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel-loaded nanoparticles with high loading efficiency and narrow-size distribution is successful. For non-invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti-tumor efficiency compared to the standard Taxol™, which is reflected in a significantly slower tumor growth compared to the NaCl control group.
AuthorsThomas Renette, Damiano Librizzi, Thomas Endres, Olivia Merkel, Moritz Beck-Broichsitter, Nadja Bege, Holger Petersen, Catherine Curdy, Thomas Kissel
JournalMacromolecular bioscience (Macromol Biosci) Vol. 12 Issue 7 Pg. 970-8 (Jul 2012) ISSN: 1616-5195 [Electronic] Germany
PMID22648959 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Carbon Radioisotopes
  • Drug Carriers
  • Polyethylenes
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • polyethylene carbonate
  • Polyglycolic Acid
  • Lactic Acid
  • Paclitaxel
Topics
  • Animals
  • Antineoplastic Agents, Phytogenic (administration & dosage, pharmacokinetics)
  • Carbon Radioisotopes
  • Drug Carriers (chemical synthesis)
  • Drug Compounding
  • Drug Stability
  • Humans
  • Lactic Acid
  • Melanoma, Experimental
  • Mice
  • Mice, Nude
  • Nanoparticles (chemistry)
  • Neoplasm Transplantation
  • Paclitaxel (administration & dosage, pharmacokinetics)
  • Particle Size
  • Polyethylenes (chemical synthesis)
  • Polyglycolic Acid
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Treatment Outcome
  • Tumor Burden (drug effects)

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