Abstract |
The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel-loaded nanoparticles with high loading efficiency and narrow-size distribution is successful. For non-invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti- tumor efficiency compared to the standard Taxol™, which is reflected in a significantly slower tumor growth compared to the NaCl control group.
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Authors | Thomas Renette, Damiano Librizzi, Thomas Endres, Olivia Merkel, Moritz Beck-Broichsitter, Nadja Bege, Holger Petersen, Catherine Curdy, Thomas Kissel |
Journal | Macromolecular bioscience
(Macromol Biosci)
Vol. 12
Issue 7
Pg. 970-8
(Jul 2012)
ISSN: 1616-5195 [Electronic] Germany |
PMID | 22648959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Carbon Radioisotopes
- Drug Carriers
- Polyethylenes
- Polylactic Acid-Polyglycolic Acid Copolymer
- polyethylene carbonate
- Polyglycolic Acid
- Lactic Acid
- Paclitaxel
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(administration & dosage, pharmacokinetics)
- Carbon Radioisotopes
- Drug Carriers
(chemical synthesis)
- Drug Compounding
- Drug Stability
- Humans
- Lactic Acid
- Melanoma, Experimental
- Mice
- Mice, Nude
- Nanoparticles
(chemistry)
- Neoplasm Transplantation
- Paclitaxel
(administration & dosage, pharmacokinetics)
- Particle Size
- Polyethylenes
(chemical synthesis)
- Polyglycolic Acid
- Polylactic Acid-Polyglycolic Acid Copolymer
- Treatment Outcome
- Tumor Burden
(drug effects)
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