Abstract | SCOPE: METHODS AND RESULTS: Orally administered lycopene (100 mg/kg bw in beadlets, n = 6) and ATRA as an endogenous RAR ligand (50 mg/kg bw, n = 6) for the induction of the retinoic acid receptor in male mice using a transgenic RARE-reporter mouse system. CONCLUSION:
Lycopene treatments induced RARE-mediated cell signalling indicated by quantified bioimaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non-identified biologically active metabolites.
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Authors | Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 56
Issue 5
Pg. 702-12
(May 2012)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 22648617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Plant Extracts
- Receptors, Retinoic Acid
- Carotenoids
- Tretinoin
- Luciferases
- Lycopene
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Topics |
- Administration, Oral
- Animals
- Carotenoids
(pharmacology)
- Female
- Gene Expression Regulation, Enzymologic
(drug effects)
- Liver
(drug effects, enzymology)
- Luciferases
(genetics)
- Luminescent Measurements
- Lycopene
- Solanum lycopersicum
- Male
- Mice
- Mice, Transgenic
- Organ Specificity
- Plant Extracts
(pharmacology)
- Receptors, Retinoic Acid
(genetics)
- Response Elements
(drug effects)
- Signal Transduction
(drug effects)
- Testis
(drug effects, metabolism)
- Time Factors
- Transcriptional Activation
- Tretinoin
(pharmacology)
- Uterus
(drug effects)
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