Abstract | BACKGROUND: METHODS: RESULTS: Among the patients with UC, 26.8% were positive for anti- HMGB1/ HMGB2 antibodies, with 85.0% specificity towards CD and a positive predictive value of 80.3%. Corticosteroids significantly suppressed the titer of anti- HMGB1/ HMGB2 antibodies. Among the patients with CD, 24.7% were positive for ASCA, with 96.2% specificity towards UC and a positive predictive value of 74.2%. Interestingly, the positivity rate of anti- HMGB/ HMGB2 antibodies was higher (35.7%) in patients with the ileitis type of CD than in patients with CD in the colon (6.2%; significant difference, P < 0.01). The specificity of anti- HMGB1/ HMGB2 antibodies in UC for CD in the colon was 93.8%. CONCLUSIONS: CD in the colon and UC can be differentially diagnosed using anti- HMGB/ HMGB2 antibodies combined with ASCA.
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Authors | Hiromasa Takaishi, Takanori Kanai, Atsushi Nakazawa, Fumihiko Sugata, Akira Nikai, Shigeo Yoshizawa, Yasuo Hamamoto, Shinsuke Funakoshi, Tomoharu Yajima, Yasushi Iwao, Masao Takemura, Shoichi Ozaki, Toshifumi Hibi |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 47
Issue 9
Pg. 969-77
(Sep 2012)
ISSN: 1435-5922 [Electronic] Japan |
PMID | 22644337
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Fungal
- Autoantibodies
- Autoantigens
- Chromosomal Proteins, Non-Histone
- HMGB1 Protein
- HMGB2 Protein
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Fungal
(blood)
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Chromosomal Proteins, Non-Histone
(immunology)
- Colitis, Ulcerative
(diagnosis, immunology)
- Crohn Disease
(diagnosis, immunology)
- Diagnosis, Differential
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescent Antibody Technique, Indirect
- HMGB1 Protein
(immunology)
- HMGB2 Protein
(immunology)
- Humans
- Male
- Middle Aged
- Saccharomyces cerevisiae
(immunology)
- Sensitivity and Specificity
- Severity of Illness Index
- Young Adult
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