The effect of selenium ions on the catabolism of prostaglandin E2 in rabbit kidney cortex.

Abstract

The effect of selenium ions on the catabolism of prostaglandin E2 by 15-hydroxy prostaglandin dehydrogenase and prostaglandin delta 13 reductase in rabbit kidney cortex was examined. Selenium ions had no effect on the 15-hydroxy prostaglandin dehydrogenase activity. On the other hand, selenium ions inhibited the prostaglandin delta 13 reductase activity at concentrations ranging from 0.05 to 0.5 mM. The effect was concentration-dependent. The inhibition by selenium ions was non-competitive with regard to NADH and 15-keto PGE2, respectively. These results suggest that selenium ions have the potential to increase 15-keto PG levels in the kidney by inhibiting the prostaglandin delta 13 reductase activity and that such action of selenium ions may participate in renal damage of selenium poisoning.

• Authors: S Sakuma, Y Fujimoto, E Hikita, Y Okano, I Yamamoto, T Fujita
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 70 Issue 1 Pg. 61-70 (Oct 1990) ISSN: 0034-5164 [Print] United States
• PMID: 2263762 (Publication Type: Journal Article)

Chemical References

• Hydroxyprostaglandin Dehydrogenases
• 15-hydroxyprostaglandin dehydrogenase
• Selenium
• Dinoprostone

Topics

• Animals
• Dinoprostone (metabolism)
• Hydroxyprostaglandin Dehydrogenases (metabolism)
• Kidney Cortex (enzymology, metabolism)
• Male
• Rabbits
• Selenium (pharmacology)