HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Percutaneous vertebroplasty for subacute and chronic painful osteoporotic vertebral compression fractures can safely be undertaken in the first year after the onset of symptoms.

Abstract
The optimal timing of percutaneous vertebroplasty as treatment for painful osteoporotic vertebral compression fractures (OVCFs) is still unclear. With the position of vertebroplasty having been challenged by recent placebo-controlled studies, appropriate timing gains importance. We investigated the relationship between the onset of symptoms - the time from fracture - and the efficacy of vertebroplasty in 115 patients with 216 painful subacute or chronic OVCFs (mean time from fracture 6.0 months (sd 2.9)). These patients were followed prospectively in the first post-operative year to assess the level of back pain and by means of health-related quality of life (HRQoL). We also investigated whether greater time from fracture resulted in a higher risk of complications or worse pre-operative condition, increased vertebral deformity or the development of nonunion of the fracture as demonstrated by the presence of an intravertebral cleft. It was found that there was an immediate and sustainable improvement in the level of back pain and HRQoL after vertebroplasty, which was independent of the time from fracture. Greater time from fracture was associated with neither worse pre-operative conditions nor increased vertebral deformity, nor with the presence of an intravertebral cleft. We conclude that vertebroplasty can be safely undertaken at an appropriate moment between two and 12 months following the onset of symptoms of an OVCF.
AuthorsM J Nieuwenhuijse, A R van Erkel, P D S Dijkstra
JournalThe Journal of bone and joint surgery. British volume (J Bone Joint Surg Br) Vol. 94 Issue 6 Pg. 815-20 (Jun 2012) ISSN: 0301-620X [Print] England
PMID22628598 (Publication Type: Journal Article)
Topics
  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Back Pain (etiology, surgery)
  • Chronic Disease
  • Female
  • Fractures, Compression (complications, surgery)
  • Humans
  • Male
  • Middle Aged
  • Minimally Invasive Surgical Procedures (methods)
  • Osteoporotic Fractures (complications, surgery)
  • Quality of Life
  • Spinal Fractures (complications, surgery)
  • Time Factors
  • Treatment Outcome
  • Vertebroplasty (adverse effects, methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: