Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease.

Abstract

Kimura disease is a rare disorder of unknown etiology, characterized by the presence of benign subcutaneous granuloma, marked peripheral blood eosinophilia and elevation of the immunglobulin E (IgE) serum level. Here, we present a case of a 12-year-old boy with Kimura disease who had a history of repeated severe influenza virus A infection. Along with the characteristic histological findings of granuloma, including eosinophil infiltration, enzyme-linked immunospot assay showed elevated numbers of IL-5- and IL-10-producing cells in the peripheral blood. Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear.

• Authors: Koa Hosoki, Masahiro Hirayama, Gail M Kephart, Hirohito Kita, Mizuho Nagao, Hiromasa Uchizono, Hidemi Toyoda, Yuko Senba, Yu Imai, Yoshihiro Komada, Toshiaki Ihara, Takao Fujisawa
• Journal: International archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 158 Suppl 1 Pg. 70-4 ( 2012) ISSN: 1423-0097 [Electronic] Switzerland
• PMID: 22627370 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 S. Karger AG, Basel.

Chemical References

• Cytokines

Topics

• Angiolymphoid Hyperplasia with Eosinophilia (diagnosis, immunology)
• Child
• Cytokines (immunology)
• Humans
• Leukocytes, Mononuclear (immunology)
• Male