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Anti Propionibacterium acnes activity of rhodomyrtone, an effective compound from Rhodomyrtus tomentosa (Aiton) Hassk. leaves.

Abstract
Propionibacterium acnes have been recognized as one of the main causative agents in pathogenesis of acne. Twenty one isolates of P. acnes isolated from acne lesions were screened for lipase and protease activity which are reported to be associated in acne and inflammation. Interestingly, all P. acnes isolates demonstrated lipase activity. Similarly, 90% of test P. acnes produced protease enzyme. Antibacterial activity of the ethanol extract of Rhodomyrtus tomentosa (Aiton) Hassk. leaves and rhodomyrtone, its principle compound were tested against P. acnes using broth macrodilution method. The MIC(90) values of the ethanol extract and rhodomyrtone were 32 and 0.5 μg/mL, respectively. The numbers of the bacterial cells were reduced at least 99% after treatment with the ethanol extract and rhodomyrtone within 72 and 24 h, respectively. Cytotoxicity test of the extract and rhodomyrtone was performed on human normal fibroblast. The IC(50) values of the ethanol extract and rhodomyrtone were 476 and more than 200 μg/mL, approximately 15 and 400 folds higher than the MIC(90) values indicating that both substances were very low cytotoxic which could be applied as topical therapeutic anti-acne agents.
AuthorsJongkon Saising, Supayang Piyawan Voravuthikunchai
JournalAnaerobe (Anaerobe) Vol. 18 Issue 4 Pg. 400-4 (Aug 2012) ISSN: 1095-8274 [Electronic] England
PMID22626672 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012. Published by Elsevier Ltd.
Chemical References
  • Anti-Bacterial Agents
  • Plant Extracts
  • Xanthones
  • rhodomyrtone
Topics
  • Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
  • Bacterial Load
  • Fibroblasts (drug effects)
  • Humans
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Myrtaceae (chemistry)
  • Plant Extracts (chemistry, pharmacology)
  • Plant Leaves (chemistry)
  • Propionibacterium acnes (drug effects, enzymology)
  • Toxicity Tests
  • Xanthones (chemistry, pharmacology)

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