Abstract | STUDY OBJECTIVE: METHODS: RESULTS: A total of 1,064 patients were enrolled (768 warfarin patients [72.2%] and 296 clopidogrel patients [27.8%]). There were 364 patients (34.2%) from Level I or II trauma centers and 700 patients (65.8%) from community hospitals. One thousand patients received a cranial CT scan in the ED. Both warfarin and clopidogrel groups had similar demographic and clinical characteristics, although concomitant aspirin use was more prevalent among patients receiving clopidogrel. The prevalence of immediate traumatic intracranial hemorrhage was higher in patients receiving clopidogrel (33/276, 12.0%; 95% confidence interval [CI] 8.4% to 16.4%) than patients receiving warfarin (37/724, 5.1%; 95% CI 3.6% to 7.0%), relative risk 2.31 (95% CI 1.48 to 3.63). Delayed traumatic intracranial hemorrhage was identified in 4 of 687 (0.6%; 95% CI 0.2% to 1.5%) patients receiving warfarin and 0 of 243 (0%; 95% CI 0% to 1.5%) patients receiving clopidogrel. CONCLUSION:
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Authors | Daniel K Nishijima, Steven R Offerman, Dustin W Ballard, David R Vinson, Uli K Chettipally, Adina S Rauchwerger, Mary E Reed, James F Holmes, Clinical Research in Emergency Services and Treatment (CREST) Network |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 59
Issue 6
Pg. 460-8.e1-7
(Jun 2012)
ISSN: 1097-6760 [Electronic] United States |
PMID | 22626015
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012. Published by Mosby, Inc. |
Chemical References |
- Anticoagulants
- Platelet Aggregation Inhibitors
- Warfarin
- Clopidogrel
- Ticlopidine
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Topics |
- Aged
- Aged, 80 and over
- Anticoagulants
(adverse effects)
- Clopidogrel
- Craniocerebral Trauma
(complications, diagnostic imaging)
- Emergency Service, Hospital
- Female
- Humans
- Intracranial Hemorrhages
(diagnostic imaging, etiology)
- Male
- Middle Aged
- Platelet Aggregation Inhibitors
(adverse effects)
- Prospective Studies
- Risk
- Ticlopidine
(adverse effects, analogs & derivatives)
- Time Factors
- Tomography, X-Ray Computed
- Warfarin
(adverse effects)
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