[Exudative enteropathy and interstitial cystitis due to systemic lupus erythematosus].

Abstract

A 33-year-old woman presented with chronic diarrhea, vomiting and anasarca due to systemic lupus erythematosus with protein-losing enteropathy, interstitial cystitis and glomerulonephritis. Methylprednisolone could not prevent aggravation of diarrhea, obstructive uropathy, and nephrotic syndrome, and prolonged intestinal ileus developed. Because of this steroid-resistance, bolus injections of cyclophosphamide (1 g i.v. monthly) were decided. Protein-losing enteropathy and ileus both disappeared rapidly following the first injection. Protein-losing enteropathy, intestinal ileus and interstitial cystitis are exceptional manifestations of systemic lupus erythematosus; steroid-resistance of the digestive manifestations has only been reported in one case and our observation is the first reporting the efficacy of cyclophosphamide.

• Authors: P Marteau, J D Grange, C Michel, J F Mosnier, S Islam, A Najman, F Mignon, F Bodin
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 14 Issue 10 Pg. 771-5 ( 1990) ISSN: 0399-8320 [Print] France
• Vernacular Title: Entéropathie exsudative et cystite interstitielle au cours d'un lupus érythémateux disséminé.
• PMID: 2262125 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Adult
• Cyclophosphamide (therapeutic use)
• Cystitis (diagnostic imaging, drug therapy, etiology)
• Female
• Humans
• Lupus Erythematosus, Systemic (complications, pathology)
• Protein-Losing Enteropathies (drug therapy, etiology)
• Urography