Abstract | BACKGROUND: METHODS: Fifty-five ARN patients (62 eyes) who had been treated with short-term or long-term oral acyclovir were identified in this retrospective study: one group treated with prolonged oral acyclovir (≥14 weeks) and the other group treated with a shorter duration of oral acyclovir (<14 weeks). The authors examined whether the prolonged treatment reduced the involvement of the contralateral eye. They also evaluated prognostic factors for visual outcome. RESULTS: Prolonged oral acyclovir treatment reduced the involvement of the contralateral eye (p = .036). The visual outcome was influenced by the timing of treatment initiation after symptom onset (p = .030), the age of the patient (p = .027), the area of retinal disease (p = .026), and the retinal detachment (p = .002). CONCLUSIONS: Prolonged oral acyclovir treatment had a significant role in preventing the involvement of the contralateral eye.
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Authors | Sohee Jeon, Hirohiko Kakizaki, Won Ki Lee, Donghyun Jee |
Journal | Ocular immunology and inflammation
(Ocul Immunol Inflamm)
Vol. 20
Issue 4
Pg. 288-92
(Aug 2012)
ISSN: 1744-5078 [Electronic] England |
PMID | 22621210
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Acyclovir
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Topics |
- Acyclovir
(therapeutic use)
- Aged
- Aged, 80 and over
- Antiviral Agents
(therapeutic use)
- Eye Infections, Viral
(drug therapy)
- Female
- Herpesviridae Infections
(drug therapy)
- Humans
- Male
- Middle Aged
- Retinal Necrosis Syndrome, Acute
(drug therapy, virology)
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
(drug effects)
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