HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of prolonged oral acyclovir treatment in acute retinal necrosis.

AbstractBACKGROUND:
To examine the effectiveness of prolonged oral acyclovir treatment in patients with acute retinal necrosis (ARN).
METHODS:
Fifty-five ARN patients (62 eyes) who had been treated with short-term or long-term oral acyclovir were identified in this retrospective study: one group treated with prolonged oral acyclovir (≥14 weeks) and the other group treated with a shorter duration of oral acyclovir (<14 weeks). The authors examined whether the prolonged treatment reduced the involvement of the contralateral eye. They also evaluated prognostic factors for visual outcome.
RESULTS:
Prolonged oral acyclovir treatment reduced the involvement of the contralateral eye (p = .036). The visual outcome was influenced by the timing of treatment initiation after symptom onset (p = .030), the age of the patient (p = .027), the area of retinal disease (p = .026), and the retinal detachment (p = .002).
CONCLUSIONS:
Prolonged oral acyclovir treatment had a significant role in preventing the involvement of the contralateral eye.
AuthorsSohee Jeon, Hirohiko Kakizaki, Won Ki Lee, Donghyun Jee
JournalOcular immunology and inflammation (Ocul Immunol Inflamm) Vol. 20 Issue 4 Pg. 288-92 (Aug 2012) ISSN: 1744-5078 [Electronic] England
PMID22621210 (Publication Type: Journal Article)
Chemical References
  • Antiviral Agents
  • Acyclovir
Topics
  • Acyclovir (therapeutic use)
  • Aged
  • Aged, 80 and over
  • Antiviral Agents (therapeutic use)
  • Eye Infections, Viral (drug therapy)
  • Female
  • Herpesviridae Infections (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Retinal Necrosis Syndrome, Acute (drug therapy, virology)
  • Retrospective Studies
  • Treatment Outcome
  • Visual Acuity (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: