[Effects of indomethacin and BCG vaccine on growth of transplanted tumors in mice].

Abstract

Continuous administration of indomethacin (IM) in drinking water (20 micrograms/ml) causes moderate inhibition of the growth of transplantable tumors in control mice but significantly increases the antitumor effect of BCG vaccine inoculated in combination with transplanted tumor cells. Hepatoma 29, insensitive to the vaccine becomes highly sensitivity to it under IM administration.

• Authors: Iu N Kurunov, V I Kaledin
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 12 Issue 6 Pg. 57-9 ( 1990) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Vliianie indometatsina i vaktsiny BTsZh na rost perevivnykh opukholeĭ u mysheĭ.
• PMID: 2261880 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• BCG Vaccine
• Indomethacin

Topics

• Adenocarcinoma (pathology, therapy)
• Animals
• BCG Vaccine (pharmacology, therapeutic use)
• Indomethacin (pharmacology, therapeutic use)
• Liver Neoplasms, Experimental (pathology, therapy)
• Lung Neoplasms (pathology, therapy)
• Mice
• Mice, Inbred CBA
• Mice, Inbred Strains
• Neoplasm Transplantation