Abstract | OBJECTIVE: METHODS: RESULTS: Of the 2,936 pregnant women included in this study, 116 (4.0%, 95% confidence interval [CI] 3.2-4.7) had preeclampsia subsequently diagnosed. The prevalence of preeclampsia was significantly higher among women with plasma kynurenic acid concentrations greater than the 95th percentile than among those with concentrations in the 25th-75th percentile (11.0% compared with 3.3%, P<.001; adjusted odds ratio 3.6, 95% CI 1.9-6.8). This association was significantly stronger in women with prepregnancy body mass index of 25 or more (P for interaction=.03; 20.4% compared with 4.2%; P<.001). No statistically significant associations of preeclampsia with other tryptophan metabolites were found. CONCLUSION: Elevated maternal plasma kynurenic acid concentrations in early pregnancy are associated with a substantial increased risk of preeclampsia in obese women. LEVEL OF EVIDENCE: II.
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Authors | Roy M Nilsen, Anne-Lise Bjørke-Monsen, Oivind Midttun, Ottar Nygård, Eva R Pedersen, Arve Ulvik, Per Magnus, Håkon K Gjessing, Stein Emil Vollset, Per Magne Ueland |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 119
Issue 6
Pg. 1243-50
(Jun 2012)
ISSN: 1873-233X [Electronic] United States |
PMID | 22617590
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Female
- Humans
- Kynurenine
(analogs & derivatives, blood, metabolism)
- Norway
(epidemiology)
- Overweight
(blood, metabolism)
- Pre-Eclampsia
(blood, diagnosis, epidemiology, metabolism)
- Pregnancy
- Prevalence
- Risk
- Tryptophan
(blood, metabolism)
- Young Adult
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