Abstract | BACKGROUND AND THE PURPOSE OF THE STUDY: METHODS: Children with a history of functional constipation were subjects of this study. One hundred and sixty children of 2-12 years old with functional constipation were randomized in two PEG and paraffin treatment groups. Patients received either 1.0-1.5 g/kg/day PEG 3350 or 1.0-1.5 ml/kg/day liquid paraffin for 4 months. Clinical efficacy was evaluated by stool and encopresis frequency/week and overall treatment success rate was compared in two groups. RESULTS AND MAJOR CONCLUSION: Compared with the baseline, defecation frequency/ week increased significantly and encopresis frequency meaningfully decreased in two groups during the period of the study. Patients using PEG 3350 had more success rate (mean: 95.3%±3.7) compared with the patients in paraffin group (mean: 87.2%±7.1) (p=0.087). Administration of PEG 3350 were associated with less adverse events than liquid paraffin. In conclusion in treatment of pediatric functional constipation, regarding clinical efficacy and safety, PEG 3350 were at least as effective as liquid paraffin and but less adverse drug events.
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Authors | Mr Rafati, H Karami, E Salehifar, A Karimzadeh |
Journal | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
(Daru)
Vol. 19
Issue 2
Pg. 154-8
( 2011)
ISSN: 2008-2231 [Electronic] Switzerland |
PMID | 22615652
(Publication Type: Journal Article)
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