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Cannabinoid-associated cell death mechanisms in tumor models (review).

Abstract
In recent years, cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to findings that they can affect the viability and invasiveness of a variety of different cancer cells. Moreover, in addition to their inhibitory effects on tumor growth and migration, angiogenesis and metastasis, the ability of these compounds to induce different pathways of cell death has been highlighted. Here, we review the most recent results generating interest in the field of death mechanisms induced by cannabinoids in cancer cells. In particular, we analyze the pathways triggered by cannabinoids to induce apoptosis or autophagy and investigate the interplay between the two processes. Overall, the results reported here suggest that the exploration of molecular mechanisms induced by cannabinoids in cancer cells can contribute to the development of safe and effective treatments in cancer therapy.
AuthorsGiuseppe Calvaruso, Ornella Pellerito, Antonietta Notaro, Michela Giuliano
JournalInternational journal of oncology (Int J Oncol) Vol. 41 Issue 2 Pg. 407-13 (Aug 2012) ISSN: 1791-2423 [Electronic] Greece
PMID22614735 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Cannabinoids
Topics
  • Animals
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Apoptosis (drug effects)
  • Autophagy (drug effects)
  • Cannabinoids (pharmacology, therapeutic use)
  • Drug Synergism
  • Humans
  • Neoplasms (drug therapy, pathology)

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