Endoscopic surveillance and primary prophylaxis sclerotherapy of esophageal varices in biliary atresia.

Abstract

OBJECTIVES:

Evidence-based recommendations on endoscopic screening and prophylactic treatment of esophageal varices in patients with biliary atresia (BA) are scarce. We assessed the efficiency of endoscopic surveillance and risk factors of esophageal varices and associated upper gastrointestinal bleeding.

METHODS:

A total of 47 consecutive children with BA and portoenterostomy underwent yearly endoscopies and prophylactic injection sclerotherapy of esophageal varices between 1987 and 2009. The median follow-up was 1.7 years (range 0.5-18.9) and overall 2-year survival 71%. Disease characteristics, clearance of jaundice, laboratory tests reflecting liver function and hypersplenism, as well as sonographic signs of portal hypertension were related to endoscopic findings and bleeding episodes.

RESULTS:

Grade 2 to 3 varices developed with similar frequency after failed (18/28, 64%) and successful portoenterostomy (10/19, 53%) in 28 patients. Following failed portoenterostomy, esophageal varices were encountered significantly earlier (8 [4-23] vs. 19 [4-165] months, P = 0.004), and they reappeared after eradication more often (16/16 vs. 4/10, P = 0.001). Varices bled only after failed portoenterostomy (13/28 vs. 0/19, P < 0.001). Increased serum bilirubin concentration >40 μmol/L at 3 months after portoenterostomy was a risk factor of upper gastrointestinal bleeding (odds ratio [OR] 17, 95% confidence interval [CI] 1.7-175, P = 0.017).

CONCLUSIONS:

In future studies as well as clinical surveillance of BA patients' varices, successful and failed portoenterostomy patients should be approached as separate groups with divergent prognoses. After failed portoenterostomy, surveillance should start early, for example, at 6 months.

• Authors: Hanna Lampela, Silja Kosola, Antti Koivusalo, Jouni Lauronen, Hannu Jalanko, Risto Rintala, Mikko P Pakarinen
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 55 Issue 5 Pg. 574-9 (Nov 2012) ISSN: 1536-4801 [Electronic] United States
• PMID: 22614114 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bilirubin

Topics

• Adolescent
• Biliary Atresia (complications)
• Bilirubin (blood)
• Child
• Child, Preschool
• Esophageal and Gastric Varices (diagnosis, epidemiology, etiology, prevention & control)
• Esophagoscopy (methods)
• Follow-Up Studies
• Gastrointestinal Hemorrhage (etiology, prevention & control)
• Humans
• Hypersplenism (etiology)
• Infant
• Infant, Newborn
• Jaundice (etiology, therapy)
• Portoenterostomy, Hepatic (methods)
• Prevalence
• Recurrence
• Risk Factors
• Sclerotherapy
• Treatment Failure