Histology-specific therapy for advanced soft tissue sarcoma and benign connective tissue tumors.

Abstract

Molecularly targeted agents have shown activity in soft tissue sarcoma (STS) and benign connective tissue tumors over the past ten years, but response rates differ by histologic subtype. The field of molecularly targeted agents in sarcoma is increasingly complex. Often, clinicians must rely on phase II data or even case series due to the rarity of these diseases. In subtypes with a clear role of specific factors in the pathophysiology of disease, such as giant cell tumor of the bone and diffuse-type tenosynovial giant cell tumor, it is reasonable to treat with newer targeted therapies, when available, in place of chemotherapy when systemic treatment is needed to control disease. In diseases without documented implication of a pathway in disease pathogenesis (e.g. soft tissue sarcoma and vascular endothelial growth factor), clear benefit from drug treatment should be established in randomized phase III trials before implementation into routine clinical practice. Histologic subtype will continue to emerge as a critical factor in treatment selection as we learn more about the molecular drivers of tumor growth and survival in different subtypes. Many of the drugs that have been recently developed affect tumor growth more than survival, therefore progression-free survival may be a more clinically relevant intermediate endpoint than objective response rate using Response Evaluation Criteria In Solid Tumors (RECIST) in early phase sarcoma trials. Because of the rarity of disease and increasing need for multidisciplinary management, patients with connective tissue tumors should be evaluated at a center with expertise in these diseases. Participation in clinical trials, when available, is highly encouraged.

• Authors: Ann W Silk, Scott M Schuetze
• Journal: Current treatment options in oncology (Curr Treat Options Oncol) Vol. 13 Issue 3 Pg. 285-98 (Sep 2012) ISSN: 1534-6277 [Electronic] United States
• PMID: 22610342 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• TOR Serine-Threonine Kinases

Topics

• Antineoplastic Agents (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Humans
• Neoplasm Grading
• Neoplasm Staging
• Neoplasms, Connective Tissue (drug therapy, pathology)
• Protein Kinase Inhibitors (pharmacology, therapeutic use)
• Sarcoma (drug therapy, pathology)
• TOR Serine-Threonine Kinases (antagonists & inhibitors)
• Treatment Outcome