Abstract | OBJECTIVE:
Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats. DESIGN: Randomized controlled trial. SETTING: Laboratory. SUBJECTS: Seven-day-old postnatal Sprague-Dawley rats. INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Control animals undergoing moderate hypoxic- ischemia endured reduced neuronal survival at 7 days with impaired neurologic function at the juvenile age compared with naïve animals. Severe hypoxic-ischemic damage produced a large cerebral infarction in controls. After moderate hypoxic- ischemia, all three noble gases improved cell survival, brain structural integrity, and neurologic function on postnatal day 40 compared with nitrogen. Interestingly, argon improved cell survival to naïve levels, whereas xenon and helium did not. When tested against more severe hypoxic-ischemic injury only, argon and xenon reduced infarct volume. Furthermore, postinjury body weight in moderate insult was lower in the helium-treated group compared with the naïve, control, and other noble gas treatment groups, whereas in the severe injurious setting, it is lower in both control and helium-treated groups than other groups. In the nondirectly injured hemisphere, argon, helium, and xenon increased the expression of Bcl-2, whereas helium and xenon increased Bcl-xL. In addition, Bax expression was enhanced in the control and helium groups. CONCLUSIONS:
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Authors | Lei Zhuang, Ting Yang, Hailin Zhao, António Rei Fidalgo, Marcela P Vizcaychipi, Robert D Sanders, Buwei Yu, Masao Takata, Mark R Johnson, Daqing Ma |
Journal | Critical care medicine
(Crit Care Med)
Vol. 40
Issue 6
Pg. 1724-30
(Jun 2012)
ISSN: 1530-0293 [Electronic] United States |
PMID | 22610177
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuroprotective Agents
- Helium
- Xenon
- Argon
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Topics |
- Animals
- Animals, Newborn
- Argon
(therapeutic use)
- Asphyxia Neonatorum
(drug therapy)
- Disease Models, Animal
- Female
- Helium
(therapeutic use)
- Humans
- Infant, Newborn
- Male
- Neuroprotective Agents
(therapeutic use)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Treatment Outcome
- Xenon
(therapeutic use)
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