[Characteristics of the course of pregnancy and labor in women with Cushing's syndrome and the condition of their progeny].

Abstract

An analysis of gestational and obstetric histories of 40 women with Cushing's disease has shown that pregnancy is contraindicated during an active phase or partial clinical remission of the disease. Pregnancy is permissible at a prolonged time following the onset of a stable clinical and hormonal remission, bilateral total adrenalectomy and compensation of chronic adrenal insufficiency. No specific therapy is required in the former situation. The adrenalectomized patients need an intensification of replacement therapy and switch to parenteral glucocorticoids ante-, intra- and postpartum. Twenty infants of mothers with Cushing's disease were examined and found to have a normal clinical and endocrine status.

• Authors: R A Manusharova, E A Benikova, I V Komissarenko, A K Cheban
• Journal: Akusherstvo i ginekologiia (Akush Ginekol (Mosk)) Issue 8 Pg. 24-6 (Aug 1990) ISSN: 0300-9092 [Print] Russia (Federation)
• Vernacular Title: Osobennosti techeniia beremennosti i rodov u zhenshchin s bolezn'iu Itsenko-Kushinga i sostoianie ikh potomstva.
• PMID: 2260742 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Child
• Cushing Syndrome (physiopathology, therapy)
• Female
• Fetus (physiopathology)
• Health Status Indicators
• Humans
• Labor, Obstetric (physiology)
• Male
• Pregnancy
• Pregnancy Complications (physiopathology, therapy)
• Prenatal Exposure Delayed Effects