Co-treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis.

Abstract

BACKGROUND:

  Retinoids have been used for the treatment of skin disorders such as acne, psoriasis, and photoaging. However, despite their beneficial effects, topical retinoids often cause severe local irritation called retinoid dermatitis. We previously developed a novel vitamin A derivative, retinyl retinoate, which induces less irritation and affords excellent tolerance. In this study, we examined whether co-treatment with topical peroxisome proliferator-activated receptor-α (PPARα) agonists (e.g. WY14643) reduce retinoid dermatitis in hairless mouse skin.

METHODS:

  The effect of concomitant treatment with a PPARα agonist on retinoid dermatitis in hairless mouse epidermis was evaluated by measuring transepidermal water loss, epidermal histology, and cytokine expression.

RESULTS:

  Retinyl retinoate induced less severe retinoid dermatitis than retinoic acid. Topical application of a PPARα agonist improved the stratum corneum structure and function, reduced mRNA expression of interleukin (IL)-1α, tumor necrosis factor-α and IL-8, and inhibited ear edema induced by retinoic acid or retinyl retinoate.

CONCLUSIONS:

  Our results indicate that PPARα agonists can potentially be used to improve retinoid dermatitis. We suggest that co-treatment with retinyl retinoate and a PPARα agonist may reduce or prevent detrimental alterations in retinoid-treated skin.

• Authors: Bora Kim, Jin E Kim, Hyuk Kim, Joo D Lee, Kang-Yell Choi, Seung H Lee
• Journal: International journal of dermatology (Int J Dermatol) Vol. 51 Issue 6 Pg. 733-41 (Jun 2012) ISSN: 1365-4632 [Electronic] England
• PMID: 22607296 (Publication Type: Journal Article)
• Copyright: © 2012 The International Society of Dermatology.

Chemical References

• Enzyme Inhibitors
• Interleukin-1alpha
• Interleukin-8
• Keratolytic Agents
• Liver X Receptors
• Orphan Nuclear Receptors
• PPAR alpha
• Pyrimidines
• RNA, Messenger
• Retinoids
• Retinyl Esters
• Tumor Necrosis Factor-alpha
• Palmitic Acid
• Tretinoin
• retinyl retinoate
• pirinixic acid

Topics

• Administration, Topical
• Animals
• Cell Differentiation
• Cell Proliferation
• Dermatitis (drug therapy, pathology)
• Enzyme Inhibitors (pharmacology)
• Epidermis (pathology)
• Female
• Interleukin-1alpha (genetics, metabolism)
• Interleukin-8 (genetics, metabolism)
• Keratolytic Agents (adverse effects)
• Liver X Receptors
• Mice
• Mice, Hairless
• Orphan Nuclear Receptors (agonists)
• PPAR alpha (agonists)
• Palmitic Acid (pharmacology)
• Pyrimidines (pharmacology)
• RNA, Messenger (metabolism)
• Retinoids (adverse effects)
• Retinyl Esters
• Tretinoin (adverse effects)
• Tumor Necrosis Factor-alpha (genetics, metabolism)
• Water Loss, Insensible