[Fever caused by fipexide. Evaluation of the national pharmacovigilance survey].

Abstract

Fourteen cases of drug fever due to fipexide were reported by a retrospective survey of a National Network of French Pharmacovigilance. 8 women, 6 men (mean age, 52 years), presented a sudden fever with a mean onset delay of 7 days after the first cure (range 2-12 days). In five cases, drug fever was the only manifestation; in other cases, it was associated with systemic or cutaneous signs. Eosinophilia was frequent (8 cases) and once, a chest picture showed an interstitial pneumonitis. Fever disappeared promptly after discontinuation of the drug and for ten patients, the rechallenge was positive within a short time. The clinical picture and laboratory tests are discussed and suggest an hypersensitivity reaction.

• Authors: C Guy, N Blay, H Rousset, V Fardeau, M Ollagnier
• Journal: Therapie (Therapie) 1990 Sep-Oct Vol. 45 Issue 5 Pg. 429-31 ISSN: 0040-5957 [Print] France
• Vernacular Title: Les fièvres au fipexide. Bilan de l'enquête nationale de pharmacovigilance.
• PMID: 2260037 (Publication Type: English Abstract, Journal Article)

Chemical References

• Piperazines
• fipexide

Topics

• Adult
• Aged
• Female
• Fever (chemically induced)
• France
• Humans
• Male
• Middle Aged
• Piperazines (adverse effects)
• Product Surveillance, Postmarketing
• Retrospective Studies