Oral absorbable fat-soluble vitamin formulation in pediatric patients with cholestasis.
Abstract | OBJECTIVE: Fat-soluble vitamin (FSV) deficiencies are common complications in pediatric patients with chronic cholestasis. The aim of the present study was to evaluate the status of FSV deficiencies in patients under present practice and to test the effect of an oral, absorbable, fat-soluble vitamin formulation (OAFSV) in these patients. METHODS: RESULTS: The proportion of patients with FSV A, D, E, and K deficiencies under conventional supplementation was 73.9%, 81.8%, 91.3%, and 20.0%, respectively. In patients with total bilirubin levels ≥3.0 mg/dL, the proportion of at least 1 FSV deficiency was 100%; and the deficiency rates of vitamin A, D, E, and K were 78.6%, 100.0%, 100.0% and 21.4%, respectively. Of the 10 patients receiving standard daily dose of OAFSV for 3 months, no adverse events or overdose effects were found. The rates of vitamin A, D, and E deficiency in the patients receiving OAFSV decreased from 80.0%, 100%, and 100%, respectively, to 70.0%, 60.0%, and 60.0% after 3 months of oral supplementation. CONCLUSIONS: High rates of FSV deficiency were found in pediatric patients with chronic cholestasis under present follow-up. OAFSV supplementation is safe and potentially effective in pediatric patients with cholestasis.
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Authors | Yu-Mei Shen, Jia-Feng Wu, Hong-Yuan Hsu, Yen-Hsuan Ni, Mei-Hwei Chang, Yu-Wen Liu, Hong-Shiee Lai, Wen-Ming Hsu, Hui-Ling Weng, Huey-Ling Chen |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 55
Issue 5
Pg. 587-91
(Nov 2012)
ISSN: 1536-4801 [Electronic] United States |
PMID | 22595974
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Vitamins
- Vitamin A
- Vitamin K
- Vitamin D
- Vitamin E
- Bilirubin
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Topics |
- Administration, Oral
- Adolescent
- Alagille Syndrome
(blood, complications, drug therapy)
- Avitaminosis
(blood, complications, drug therapy, epidemiology)
- Biliary Atresia
(blood, complications, drug therapy)
- Bilirubin
(blood)
- Child
- Child, Preschool
- Cholestasis
(blood, drug therapy, etiology)
- Cholestasis, Intrahepatic
(blood, complications, drug therapy)
- Dietary Supplements
- Female
- Humans
- Infant
- Male
- Solubility
- Vitamin A
(blood, therapeutic use)
- Vitamin D
(blood, therapeutic use)
- Vitamin E
(blood, therapeutic use)
- Vitamin K
(blood, therapeutic use)
- Vitamins
(blood, therapeutic use)
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