HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Recent developments in the pharmacological properties of 4'-geranyloxyferulic acid, a colon cancer chemopreventive agent of natural origin.

Abstract
3-(4'-Geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (4'-geranyloxyferulic acid, GOFA) is a secondary metabolite biosynthetically related to ferulic acid in which a geranyl chain is attached to the phenolic group, extracted in 1966 from Acronychia baueri Schott (Fam. Rutaceae). In the last decade the pharmacological properties of the title compound began to be characterized, revealing its good activity as anti-inflammatory and dietary feeding cancer chemopreventive agent. The aim of this review is to examine in detail the recently reported properties of 4'-geranyloxyferulic acid from a chemical and pharmacological point of view, including the recent acquisition about its mechanism of action.
AuthorsSalvatore Genovese, Francesco Epifano
JournalCurrent drug targets (Curr Drug Targets) Vol. 13 Issue 8 Pg. 1083-8 (Jul 2012) ISSN: 1873-5592 [Electronic] United Arab Emirates
PMID22594476 (Publication Type: Journal Article, Review)
Chemical References
  • 4'-geranyloxyferulic acid
  • Anti-Bacterial Agents
  • Anticarcinogenic Agents
  • Coumaric Acids
  • Neuroprotective Agents
Topics
  • Anti-Bacterial Agents (pharmacology)
  • Anticarcinogenic Agents (isolation & purification, pharmacology)
  • Colonic Neoplasms (prevention & control)
  • Coumaric Acids (isolation & purification, pharmacology)
  • Humans
  • Neuroprotective Agents (pharmacology)
  • Rutaceae (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: