Effects of metabolic inhibitors and hypoxia on the ATP, ADP and AMP content of the rabbit carotid body in vitro: the metabolic hypothesis in question.

Abstract

The effects of metabolic inhibitors (cyanide, antimycin) and hypoxia on the nucleotide content of the carotid body were investigated in vitro. The mean ATP content of carotid bodies superfused for 1 h in normoxic conditions was around 200 pmol/organ. Whereas metabolic inhibitors induced a decrease in ATP and an increase in AMP, hypoxia (10% O2 in N2, either 4 or 30 min) did not induce any significant change in nucleotide content. The significance of these results is discussed with regard to the metabolic hypothesis.

• Authors: A Verna, N Talib, M Roumy, A Pradet
• Journal: Neuroscience letters (Neurosci Lett) Vol. 116 Issue 1-2 Pg. 156-61 (Aug 14 1990) ISSN: 0304-3940 [Print] Ireland
• PMID: 2259444 (Publication Type: Journal Article)

Chemical References

• antimycin
• Adenosine Monophosphate
• Adenosine Diphosphate
• Antimycin A
• Adenosine Triphosphate
• Sodium Cyanide

Topics

• Adenosine Diphosphate (metabolism)
• Adenosine Monophosphate (metabolism)
• Adenosine Triphosphate (metabolism)
• Animals
• Antimycin A (analogs & derivatives, pharmacology)
• Carotid Body (drug effects, metabolism)
• Female
• Hypoxia (metabolism)
• In Vitro Techniques
• Kinetics
• Methods
• Models, Biological
• Rabbits
• Sodium Cyanide (pharmacology)