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Sequential use with imiquimod and surgery in extramammary Paget's disease.

Abstract
Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma which occurs in areas rich in apocrine glands. Although surgery is the treatment of choice, numerous noninvasive treatments have been tried. There are studies that have demonstrated the efficacy of imiquimod to treat Extramammary Paget's disease, but we found no mention in the literature of its use as neoadjuvant therapy previous to surgery excision. We present a case of a large plaque of extramammary Paget's disease successfully treated with imiquimod and minor surgery of the residual disease.
AuthorsF Toledo, J F Silvestre, L Cuesta, I Ballester, N Latorre, A Monteagudo
JournalDermatologic therapy (Dermatol Ther) 2012 Jan-Feb Vol. 25 Issue 1 Pg. 82-5 ISSN: 1529-8019 [Electronic] United States
PMID22591501 (Publication Type: Case Reports, Journal Article)
Copyright© 2012 Wiley Periodicals, Inc.
Chemical References
  • Aminoquinolines
  • Antineoplastic Agents
  • imiquimod
Topics
  • Adenocarcinoma (drug therapy, pathology, surgery)
  • Aminoquinolines (administration & dosage, therapeutic use)
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Combined Modality Therapy
  • Female
  • Humans
  • Middle Aged
  • Neoadjuvant Therapy (methods)
  • Paget Disease, Extramammary (drug therapy, pathology, surgery)
  • Skin Neoplasms (drug therapy, pathology, surgery)
  • Treatment Outcome

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