HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Efficacy of enterocin S760 in treatment of mice with anthrax infection due to Bacillus anthracis M-71].

Abstract
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.
AuthorsE A Svetoch, A I Borzilov, B V Eruslanov, O V Korobova, T I Kombarova, V P Levchuk, M G Teĭmurazov, Iu G Stepanshin, L I Marinin, I A Diatlov
JournalAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 56 Issue 9-10 Pg. 13-8 ( 2011) ISSN: 0235-2990 [Print] Russia (Federation)
PMID22586898 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Bacteriocins
  • bacteriocin S760, Enterococcus faecium
Topics
  • Animals
  • Anthrax (drug therapy)
  • Anti-Bacterial Agents (administration & dosage, isolation & purification)
  • Bacillus anthracis (drug effects)
  • Bacteriocins (administration & dosage, isolation & purification)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Enterococcus faecium (chemistry)
  • Mice

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: