Abstract |
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B. anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.
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Authors | E A Svetoch, A I Borzilov, B V Eruslanov, O V Korobova, T I Kombarova, V P Levchuk, M G Teĭmurazov, Iu G Stepanshin, L I Marinin, I A Diatlov |
Journal | Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
(Antibiot Khimioter)
Vol. 56
Issue 9-10
Pg. 13-8
( 2011)
ISSN: 0235-2990 [Print] Russia (Federation) |
PMID | 22586898
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Bacteriocins
- bacteriocin S760, Enterococcus faecium
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Topics |
- Animals
- Anthrax
(drug therapy)
- Anti-Bacterial Agents
(administration & dosage, isolation & purification)
- Bacillus anthracis
(drug effects)
- Bacteriocins
(administration & dosage, isolation & purification)
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Enterococcus faecium
(chemistry)
- Mice
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