The role of milk sialyllactose in intestinal bacterial colonization.

Abstract

Milk oligosaccharides influence the composition of intestinal microbiota and thereby mucosal inflammation. Some of the major milk oligosaccharides are α2,3-sialyllactose (3SL) and α2,6-sialyllactose, which are mainly produced by the sialyltransferases ST3GAL4 and ST6GAL1, respectively. Recently, we showed that mice fed milk deficient in 3SL were more resistant to dextran sulfate sodium-induced colitis. By contrast, the exposure to milk containing or deficient in 3SL had no impact on the development of mucosal leukocyte populations. Milk 3SL mainly affected the colonization of the intestine by clostridial cluster IV bacteria.

• Authors: G Adrienne Weiss, Thierry Hennet
• Journal: Advances in nutrition (Bethesda, Md.) (Adv Nutr) Vol. 3 Issue 3 Pg. 483S-8S (May 01 2012) ISSN: 2156-5376 [Electronic] United States
• PMID: 22585928 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oligosaccharides
• Dextran Sulfate
• Sialyltransferases
• Lactose

Topics

• Animals
• Bifidobacterium (drug effects, isolation & purification)
• Colitis (chemically induced, drug therapy, physiopathology)
• Dextran Sulfate (adverse effects, metabolism)
• Intestinal Mucosa (drug effects, microbiology)
• Lactose (analogs & derivatives)
• Metagenome (drug effects)
• Mice
• Milk (chemistry)
• Oligosaccharides (pharmacology)
• Sialyltransferases (genetics, metabolism)