Antiangiogenic effects of p-coumaric acid in human endothelial cells.

Abstract

p-Coumaric acid, a hydroxy derivative of cinnamic acid, has been known to possess antioxidant and anticancer activities. Despite its potential contribution to chemopreventive effects, the mechanism by which p-coumaric acid exerts its antiangiogenic actions remains elusive. In this study, we revealed that p-coumaric acid inhibited the sprouting of endothelial cells in rat aortic rings and inhibited the tube formation and migration of endothelial cells. We observed that p-coumaric acid could downregulate mRNA expression levels of the key angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor. Also, we demonstrated that p-coumaric acid inhibited both the AKT and ERK signaling pathways, which are known to be crucial for angiogenesis. Using a mouse model, we also showed that p-coumaric acid effectively suppressed tumor growth in vivo by lowering hemoglobin contents. Collectively, these findings indicate that p-coumaric acid possesses potent anticancer properties due to the inhibition of angiogenesis in vivo.

• Authors: Chang-Seok Kong, Chul-Ho Jeong, Jae-Sun Choi, Kil-Jung Kim, Joo-Won Jeong
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 27 Issue 3 Pg. 317-23 (Mar 2013) ISSN: 1099-1573 [Electronic] England
• PMID: 22585412 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 John Wiley & Sons, Ltd

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Coumaric Acids
• Propionates
• Reactive Oxygen Species
• Vascular Endothelial Growth Factor A
• Fibroblast Growth Factor 2
• p-coumaric acid

Topics

• Adenocarcinoma (blood supply)
• Angiogenesis Inhibitors (pharmacology)
• Animals
• Antineoplastic Agents (pharmacology)
• Aorta (cytology)
• Cell Line
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Coumaric Acids (pharmacology)
• Down-Regulation (drug effects)
• Endothelial Cells (drug effects)
• Fibroblast Growth Factor 2 (metabolism)
• Humans
• In Vitro Techniques
• Male
• Mice
• Mice, Inbred BALB C
• Neovascularization, Pathologic (drug therapy)
• Propionates
• Rats
• Reactive Oxygen Species (metabolism)
• Signal Transduction (drug effects)
• Vascular Endothelial Growth Factor A (metabolism)