Charge-conversional poly(amino acid)s derivatives as a drug delivery carrier in response to the tumor environment.

Abstract

A charge-converting and pH-dependent nanocarrier was achieved by conjugating 2,3-dimethylmaleic anhydride (DMMA) to the amino group of an octadecyl grafted poly (2-hydroxyethyl aspartamide) (PHEA-g-C(18)-NH(2)) backbone, thereby forming a spherical micelle. PHEA, a poly(amino acid)s derivative, was derived from poly(succinimide), which is biocompatible and biodegradable. DMMA, a detachable component at the tumor site, was added, preventing aggregation with negative blood serum and enhancing the nanocarrier's cellular uptake. The polymeric micelle was comprehensively characterized and doxorubicin was encapsulated successively. The cellular uptake and anticancer therapeutic effect were evaluated by flow cytometry, confocal laser scanning microscopy, and a MTT assay. The properties of the nanocarrier can further be exploited to develop an early detection module for cancer. The present work is also expected to advance the study of designing smart carriers for drug and gene delivery.

• Authors: Se Rim Yoon, Hee-Man Yang, Chan Woo Park, Sujin Lim, Bong Hyun Chung, Jong-Duk Kim
• Journal: Journal of biomedical materials research. Part A (J Biomed Mater Res A) Vol. 100 Issue 8 Pg. 2027-33 (Aug 2012) ISSN: 1552-4965 [Electronic] United States
• PMID: 22581644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Wiley Periodicals, Inc.

Chemical References

• Amino Acids
• Drug Carriers
• Maleic Anhydrides
• Polymers
• 2,3-dimethylmaleic anhydride
• Doxorubicin

Topics

• Amino Acids (chemistry)
• Cell Death (drug effects)
• Cell Line, Tumor
• Doxorubicin (pharmacology)
• Drug Carriers (chemistry)
• Drug Delivery Systems (methods)
• Humans
• Hydrogen-Ion Concentration (drug effects)
• Hydrolysis (drug effects)
• Light
• Magnetic Resonance Spectroscopy
• Maleic Anhydrides (chemistry)
• Particle Size
• Polymers (chemistry)
• Scattering, Radiation
• Tumor Microenvironment (drug effects)