Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry.

Abstract

Based on the advantages of natural products in new anti-cancer drug development, we synthesized a series of novel benzopyran-4-one derivatives and evaluated their in vitro anti-cancer activities. The bioassays showed that the majority of the resultant compounds exerted anti-tumor effect against six human cancer cell lines to various extents, which supported the rationale of the design. Compound 5s exhibited highest potency of all the synthesized compounds.

• Authors: Yikai Zhang, Zhiliang Lv, Hanyu Zhong, Dongping Geng, Mingfeng Zhang, Tao Zhang, Yongmei Li, Ke Li
• Journal: European journal of medicinal chemistry (Eur J Med Chem) Vol. 53 Pg. 356-63 (Jul 2012) ISSN: 1768-3254 [Electronic] France
• PMID: 22579780 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antineoplastic Agents
• Coumarins
• geiparvarin

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Chemistry Techniques, Synthetic (methods)
• Click Chemistry
• Coumarins (chemical synthesis, chemistry, pharmacology)
• Humans