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Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats.

Abstract
In the present study, polysaccharides were extracted from the Lycium chinensis (LCP). Rats were divided into four groups. Two groups (Groups A) were maintained on the basal diet, whereas the remaining three groups (Groups B, C and D) had free access to the basal diet and were orally fed with LCP at 200 mg/kg b.w. for Group B, 400 mg/kg b.w. for Group C and 600 mg/kg b.w. for Group D, respectively. Following 4 weeks of this dietary regimen, hepatocarcinogenesis was initiated in all animals by a single intraperitoneal DENA (Sigma-Aldrich, St. Louis, MO, USA) injection at a dose of 200 mg/kg body weight (mixed with peanut oil). Results still showed that L. chinensis polysaccharides (LCP) increased spleen, thymus indexs, antioxidant enzymes activities and decreased oxidative injury. In addition, LCP still significantly affect VEGF and Cyclin D1 proteins expression in liver cancer rats. It can be concluded that LCP exhibited remarkable protective effects against diethylnitrosamine (DEN)-induced oxidative hepatic injury in liver cancer rats.
AuthorsBoKang Cui, YanFeng Chen, Su Liu, Jun Wang, ShuHong Li, QiBo Wang, ShengPing Li, MinShan Chen, XiaoJun Lin
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 51 Issue 3 Pg. 314-8 (Oct 2012) ISSN: 1879-0003 [Electronic] Netherlands
PMID22579736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Polysaccharides
  • Vascular Endothelial Growth Factor A
  • Cyclin D1
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, pharmacology)
  • Cyclin D1 (metabolism)
  • Liver (drug effects, metabolism)
  • Liver Neoplasms, Experimental (metabolism)
  • Lycium (chemistry)
  • Polysaccharides (administration & dosage, pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Spleen (drug effects, metabolism)
  • Thymus Gland (drug effects, metabolism)
  • Vascular Endothelial Growth Factor A (metabolism)

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