Abstract | BACKGROUND: The seroprevalence and seroincidence of novel influenza A infection among HIV-infected patients, who were believed to have more severe outcomes than healthy individuals, are rarely investigated in the era of highly active antiretroviral therapy ( HAART). Our aim was to determine the seroprevalence and seroincidence of novel influenza A infection among HIV-infected patients in Taiwan. METHODS: Between September and November 2009, before the implementation of a nationwide vaccination for novel influenza A in Taiwan, 931 HIV-infected patients and 566 persons seeking voluntary counseling and testing (VCT) for HIV infection at our university hospital were enrolled in this study. Antibody responses to novel influenza A were determined using a hemagglutination-inhibition (HI) assay. RESULTS: HIV-infected patients had a significantly lower seroprevalence of novel influenza A infection than VCT clients (14.7% vs. 33.9%, p < 0.001). The seroincidence of novel influenza A infection among HIV-infected patients was 9.4% (95% confidence interval [CI]: 7.6-11.4). On the multivariate analysis, heterosexual (odds ratio [OR]: 1.89; 95% CI: 1.105-3.227) and baseline HI titer (OR: 1.02; 95% CI: 1.001-1.038) were significantly associated with seroconversion to novel influenza A virus. CONCLUSION: HIV-infected patients demonstrated a lower seroprevalence of novel influenza A infection than HIV-uninfected patients in Taiwan in the HAART era. Among HIV-infected patients, seroconversion to novel influenza A virus, which was infrequent during the 2009 influenza epidemic, was associated with heterosexual behavior and baseline HI titer.
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Authors | Chien-Ching Hung, Tai-Ling Zhao, Hsin-Yun Sun, Yi-Fang Yang, Yi-Ching Su, Shu-Fang Chang, Wen-Chun Liu, Cheng-Hsin Wu, Sui-Yuan Chang, Shan-Chwen Chang |
Journal | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
(J Microbiol Immunol Infect)
Vol. 46
Issue 3
Pg. 151-7
(Jun 2013)
ISSN: 1995-9133 [Electronic] England |
PMID | 22579505
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Viral
(blood)
- Antiretroviral Therapy, Highly Active
(methods)
- Child
- Child, Preschool
- Female
- HIV Infections
(complications, drug therapy)
- Hemagglutination Inhibition Tests
- Hospitals, University
- Humans
- Incidence
- Infant
- Influenza A Virus, H1N1 Subtype
(immunology)
- Influenza, Human
(epidemiology, immunology)
- Male
- Middle Aged
- Seroepidemiologic Studies
- Taiwan
- Young Adult
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