The effects of different routes of injection on the biochemistry of adhesion site proteoglycans in metastatic v-Ki-ras-transformed 3T3 cells.

Abstract

This study compared HSPG and CSPG in adhesion sites of isogenic metastatic lung tumor cells (v-Ki-ras-transformed 3T3 cells) after injection by different routes (IV and footpad) into athymic nude mice. The proportion of HSPG was significantly greater in experimental lung metastatic cell (IV injection) than in spontaneously metastatic cells. The proportion of CSPG in these two groups of metastatic lung cells did not differ significantly. In addition, the proportion of HSPG and CSPG in spontaneously metastatic lung tumor cells was similar, unlike experimental metastatic tumor cells.

• Authors: M A Kosir, K L Houmiel, L A Culp
• Journal: Current surgery (Curr Surg) 1990 Sep-Oct Vol. 47 Issue 5 Pg. 347-9 ISSN: 0149-7944 [Print] United States
• PMID: 2257753 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chondroitin Sulfate Proteoglycans
• Heparan Sulfate Proteoglycans
• Heparitin Sulfate

Topics

• Animals
• Cell Adhesion
• Cell Line, Transformed
• Chondroitin Sulfate Proteoglycans (analysis)
• Genes, ras
• Heparan Sulfate Proteoglycans
• Heparitin Sulfate (analysis)
• Injections
• Lung Neoplasms (chemistry, secondary)
• Mice
• Mice, Inbred BALB C
• Mice, Nude