The effect of adipose-derived stem cell-cultured media on oxazolone treated atopic dermatitis-like murine model.

Abstract

BACKGROUND:

A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose-derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones.

OBJECTIVE:

We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis.

METHODS:

ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice.

RESULTS:

Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media-treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3.

CONCLUSION:

Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.

• Authors: Hae-Jin Lee, Minyoung Jung, Jae-Hong Kim, Na Young Yoon, Eung Ho Choi
• Journal: Annals of dermatology (Ann Dermatol) Vol. 24 Issue 2 Pg. 181-8 (May 2012) ISSN: 2005-3894 [Electronic] Korea (South)
• PMID: 22577269 (Publication Type: Journal Article)