A novel bFGF antagonist peptide inhibits breast cancer cell growth.

Abstract	Breast cancer is the most common type of cancer in women worldwide. Elevated expression of the basic fibroblast growth factor (bFGF) has been found in patients suffering from breast cancer. We previously obtained a high-afﬁnity bFGF-binding peptide (named P7) from a phage-display random heptapeptide library. In this study, we show that P7 peptides significantly inhibits the proliferation of the bFGF-stimulated MDA-MB-231 breast cancer cell line. Additional experiments revealed that the mechanisms of the P7 peptide inhibition of the cell proliferation of breast cancer cells stimulated with bFGF in vitro involved cell cycle arrest at the G0/G1 phase, blockade of the activation of Erk and P38 cascades and the upregulation of the expression of the growth inhibitor, proliferation-associated protein 2G4. These results suggest that the bFGF-binding peptide may have therapeutic potential in breast cancer therapy.
Authors	Quchou Li, Susu Gao, Yonglin Yu, Wenhui Wang, Xilei Chen, Ruixue Wang, Tao Li, Cong Wang, Xiaokun Li, Xiaoping Wu
Journal	Molecular medicine reports (Mol Med Rep) Vol. 6 Issue 1 Pg. 210-4 (07 2012) ISSN: 1791-3004 [Electronic] Greece
PMID	22576745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adaptor Proteins, Signal Transducing Growth Inhibitors Oligopeptides PA2G4 protein, human Peptides RNA-Binding Proteins prolyl-leucyl-leucyl-glutaminyl-alanyl-threonyl-leucine Fibroblast Growth Factor 2 Mitogen-Activated Protein Kinases
Topics	Adaptor Proteins, Signal Transducing (metabolism) Amino Acid Sequence Breast Neoplasms (metabolism) Cell Cycle (drug effects) Cell Line, Tumor Cell Proliferation (drug effects) Enzyme Activation (drug effects) Female Fibroblast Growth Factor 2 (antagonists & inhibitors, pharmacology) Growth Inhibitors (pharmacology) Humans Mitogen-Activated Protein Kinases (metabolism) Oligopeptides (chemistry, pharmacology) Peptides (chemistry, pharmacology) RNA-Binding Proteins (metabolism)

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