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Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin.

Abstract
AD, sleep and circadian rhythm physiology display an intricate relationship. On the one hand, AD pathology leads to sleep and circadian disturbances, with a clear negative influence on quality of life. On the other hand, there is increasing evidence that both sleep and circadian regulating systems exert an influence on AD pathology. In this review we describe the impairments of both sleep regulating systems and circadian rhythms in AD and their link to clinical symptoms, as this may increase knowledge on appropriate diagnosis and adequate treatment of sleep problems in AD. Furthermore we discuss how sleep regulating systems, and especially neurotransmitters such as melatonin and hypocretin, may affect AD pathophysiology, as this may provide a role for lack of sleep and circadian rhythm deterioration in the onset of AD.
AuthorsDiane Slats, Jurgen A H R Claassen, Marcel M Verbeek, Sebastiaan Overeem
JournalAgeing research reviews (Ageing Res Rev) Vol. 12 Issue 1 Pg. 188-200 (Jan 2013) ISSN: 1872-9649 [Electronic] England
PMID22575905 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins
  • Melatonin
Topics
  • Alzheimer Disease (complications, metabolism, physiopathology, psychology)
  • Circadian Rhythm (physiology)
  • Humans
  • Intracellular Signaling Peptides and Proteins (metabolism, physiology)
  • Melatonin (metabolism, physiology)
  • Neuropeptides (metabolism, physiology)
  • Orexins
  • Sleep (physiology)
  • Sleep Wake Disorders (etiology, physiopathology)

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