Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents.

Abstract

OBJECTIVE:

To evaluate the cause-effect relationships between serum levels of uric acid (UA) and metabolic syndrome (MetS) in an adolescent-male cohort that was followed for 2.7 years.

STUDY DESIGN:

We enrolled male adolescents aged between 10 and 15 years at the baseline. A total of 613 subjects were divided into quartiles according to their UA levels, from UA-1 (the lowest) to UA-4 (the highest).

RESULTS:

After the mean follow-up period of 2.7 ± 0.97 years, 19 (3.1%) subjects developed MetS. Waist circumference (WC), systolic blood pressure, high density lipoprotein cholesterol (HDL-C), and log triglyceride levels were significantly related to baseline UA levels. Compared with the UA-1 group, subjects in the UA-4 group had significantly higher OR for abnormal WC, blood pressure, and HDL-C at the end of follow-up and had a 6.39-fold higher OR (95% CI 1.41-29.08; P < .05) for having MetS. Subjects with UA >7.6 mg/dL had a 4.32 (95% CI 1.57-11.93) higher risk of developing MetS.

CONCLUSIONS:

In this longitudinal study, we found that serum UA is correlated with future WC, systolic blood pressure, triglyceride, and HDL-C and is a risk factor for developing MetS. UA might be valuable in predicting adolescent MetS.

• Authors: Jen-Yu Wang, Yen-Lin Chen, Chun-Hsien Hsu, Sai-Hung Tang, Chung-Ze Wu, Dee Pei
• Journal: The Journal of pediatrics (J Pediatr) Vol. 161 Issue 4 Pg. 753-6.e2 (Oct 2012) ISSN: 1097-6833 [Electronic] United States
• PMID: 22575243 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Mosby, Inc. All rights reserved.

Chemical References

• Triglycerides
• Uric Acid

Topics

• Adolescent
• Blood Pressure
• Humans
• Male
• Metabolic Syndrome (diagnosis)
• ROC Curve
• Risk Factors
• Triglycerides (analysis)
• Uric Acid (blood)