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Low 25-hydroxyvitamin D predicts the onset of mobility limitation and disability in community-dwelling older adults: the Health ABC Study.

AbstractBACKGROUND:
Although low 25-hydroxyvitamin D (25(OH)D) is prevalent among older adults and is associated with poor physical function, longitudinal studies examining vitamin D status and physical function are lacking. We examined the association between 25(OH)D, parathyroid hormone (PTH), and the onset of mobility limitation and disability over 6 years of follow-up in community-dwelling, initially well-functioning older adults participating in the Health, Aging and Body Composition study (n = 2,099).
METHODS:
Serum 25(OH)D and PTH were measured at the 12-month follow-up visit (1998-1999). Mobility limitation and disability (any/severe difficulty walking 1/4 mile or climbing 10 steps) was assessed semiannually over 6 years of follow-up. The association between 25(OH)D, PTH, and mobility limitation and disability was examined using Cox proportional hazard regression models adjusted for demographics, season, behavioral characteristics, and chronic conditions.
RESULTS:
At baseline, 28.9% of the participants had 25(OH)D <50 nmol/L and 36.1% had 25(OH)D of 50 to <75 nmol/L. Participants with 25(OH)D <50 and 50 to <75 nmol/L were at greater risk of developing mobility limitation (HR (95% CI): 1.29 (1.04-1.61) and 1.27 (1.05-1.53), respectively) and mobility disability (HR (95% CI): 1.93 (1.32-2.81) and 1.30 (0.92-1.83), respectively) over 6 years of follow-up compared with participants with 25(OH)D ≥75 nmol/L. Elevated PTH, however, was not significantly associated with developing mobility limitation or disability.
CONCLUSIONS:
Low 25(OH)D was associated with an increased risk of mobility limitation and disability in community-dwelling, initially well-functioning black and white older adults. Prevention or treatment of low 25(OH)D may provide a pathway for reducing the burden of mobility disability in older adults.
AuthorsDenise K Houston, Rebecca H Neiberg, Janet A Tooze, Dorothy B Hausman, Mary Ann Johnson, Jane A Cauley, Doug C Bauer, M Kyla Shea, Gary G Schwartz, Jeff D Williamson, Tamara B Harris, Stephen B Kritchevsky, Health ABC Study
JournalThe journals of gerontology. Series A, Biological sciences and medical sciences (J Gerontol A Biol Sci Med Sci) Vol. 68 Issue 2 Pg. 181-7 (Feb 2013) ISSN: 1758-535X [Electronic] United States
PMID22573914 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Parathyroid Hormone
  • Vitamin D
  • 25-hydroxyvitamin D
Topics
  • Aged
  • Aged, 80 and over
  • Aging (blood, physiology)
  • Biomarkers (blood)
  • Cohort Studies
  • Disabled Persons
  • Female
  • Humans
  • Male
  • Mobility Limitation
  • Parathyroid Hormone (blood)
  • Pennsylvania
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Tennessee
  • Vitamin D (analogs & derivatives, blood)

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