Abstract | INTRODUCTION: Surgical excision with margins of 0.5cm is the standard treatment for lentigo maligna (LM). Excision, however, is often incomplete as many of these tumors have indistinct borders. OBJECTIVE: To identify clinical predictors of subclinical extension in primary and recurrent LM of the head and thereby determine which lesions might require wider surgical margins. MATERIAL AND METHODS: We reviewed the clinical records of patients with LM of the head treated definitively with conventional surgical excision or slow micrographic Mohs surgery (MMS) at the dermatology department of Instituto Valenciano de Oncología between January 1993 and April 2011. RESULTS:
Surgical margins larger than 0.5cm were required in 69.2% of recurrent LM and 26.5% of primary LM. Factors associated with the need for wider margins were prior treatment that might have interfered with the clinical delineation of the border, lesions in the center of the face, and skin phototypes III to V. CONCLUSIONS:
Surgical margins of 0.5cm are inadequate for the treatment of a considerable number of LM lesions located on the head, particularly if these are recurrent. Slow MMS using paraffin-embedded sections appears to be the treatment of choice in such cases, particularly for recurrent lesions or lesions with poorly defined borders or possible subclinical extension.
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Authors | H Hilari, D Llorca, V Traves, A Villanueva, C Serra-Guillén, C Requena, B Llombart, O Sanmartín, C Guillén, E Nagore |
Journal | Actas dermo-sifiliograficas
(Actas Dermosifiliogr)
Vol. 103
Issue 7
Pg. 614-23
(Sep 2012)
ISSN: 1578-2190 [Electronic] Spain |
PMID | 22572575
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2011 Elsevier España, S.L. y AEDV. All rights reserved. |
Chemical References |
- Aminoquinolines
- Antineoplastic Agents
- Imiquimod
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Topics |
- Aged
- Aminoquinolines
(therapeutic use)
- Antineoplastic Agents
(therapeutic use)
- Combined Modality Therapy
- Female
- Head and Neck Neoplasms
(drug therapy, pathology, surgery)
- Humans
- Hutchinson's Melanotic Freckle
(drug therapy, pathology, surgery)
- Imiquimod
- Male
- Middle Aged
- Mohs Surgery
(methods)
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(pathology, prevention & control, surgery)
- Neoplasm, Residual
- Paraffin Embedding
- Reoperation
- Retrospective Studies
- Skin Neoplasms
(drug therapy, pathology, surgery)
- Skin Pigmentation
- Treatment Outcome
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