Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.

Abstract

AIMS AND OBJECTIVES:

Pregnancy associated plasma protein-A (PAPP-A), a metalloproteinase plays a pivotal role in the pathogenesis of atherosclerosis. Recent studies have reported that elevated levels of PAPP-A, signal the onset of acute coronary syndrome (ACS). We, therefore, proposed to study the analytical competence of PAPP-A in patients admitted to the emergency department with chest pain and finally diagnosed as ACS.

METHODS AND RESULTS:

Pregnancy associated plasma protein-A was measured using enzyme-linked immunosorbent assay (ELISA) in 485 patients admitted to emergency care unit, of which 89 patients were diagnosed as Non-cardiac chest pain (NCCP). Elevated levels of PAPP-A were observed in patients diagnosed as ACS on comparison with the controls. Receiver operator characteristic (ROC) curve analysis showed PAPP-A to be a good discriminator between ischaemic and non-ischaemic patients. The area under the curve was found to be 0.904, 95% CI (0.874-0.929) with 90% sensitivity and 85% specificity (P< 0.0001). The cut-off value from the ROC curve was 0.55 μg/mL above which PAPP-A was considered to be positive.

CONCLUSION:

Pregnancy associated plasma protein-A seems to be a promising biomarker for identification and risk stratification for patients with ACS.

• Authors: Priya Gururajan, Prema Gurumurthy, Pradeep Nayar, G Srinivasa Nageswara Rao, R Sai Babu, A Sarasabharati, K M Cherian
• Journal: Indian heart journal (Indian Heart J) 2012 Mar-Apr Vol. 64 Issue 2 Pg. 141-5 ISSN: 0019-4832 [Print] India
• PMID: 22572488 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Troponin I
• Creatine Kinase, MB Form
• Pregnancy-Associated Plasma Protein-A

Topics

• Acute Coronary Syndrome (diagnosis)
• Adult
• Aged
• Area Under Curve
• Biomarkers (blood)
• Creatine Kinase, MB Form (blood)
• Female
• Humans
• Male
• Middle Aged
• Pregnancy
• Pregnancy-Associated Plasma Protein-A (analysis)
• ROC Curve
• Troponin I (blood)